Case Of Severe Unconjugated Hyperbilirubinemia In A Neonate Heterozygous For Gilbert Syndrome
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منابع مشابه
Case of Severe Unconjugated Hyperbilirubinemia in a Neonate Heterozygous for Gilbert Syndrome
We present an unusual case of unconjugated hyperbilirubinemia in a 6 day old infant. The bilirubin peaked at 20.1/ 0.6 mg/dL. A work-up for a hemolytic process or metabolic disorder was negative. Crigler-Najjar was suspected. Phenobarbital was given for 3 days with no ������ change in bilirubin level. He was discharged home after 20 days of phototherapy with a bilirubin of 3.1/0.4 mg/dL. Five m...
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We experienced a case of a 19-year-old man with Gilbert syndrome with concomitant hereditary spherocytosis. The patient presented with moderate unconjugated hyperbilirubinemia, and inherited etiology was strongly suspected. The diagnosis of Gilbert syndrome was confirmed by the genetic analysis of the UGT1A1 gene, demonstrating UGT1A1*28 and compound heterozygote UGT1A1*6. In addition, since th...
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Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. Phototherapy, however, has several known disadvantages while exchange transfusion is associated with a significant morbidity, and even mortality. These harmful effects indicate the n...
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Biopyrrin is an oxidative metabolite of bilirubin. Biopyrrin is a tripyrrol moiety of bilirubin, including two regioisomers (biotripyrrin-a, 1,14,15,17tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16Htripyrrin-8,12-dipropionic acid and biotripyrrin-b, 1,14,15,17-tetrahydro-3,7,13-trimethyl-1,14-deoxy2-vinyl-16H-tripyrrin-8,12-dipropionic acid: Fig. 1). For many years, bilirubin was regarded as...
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OBJECTIVE To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. METHODS A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines from the Cochrane review group and the PRISMA statemen...
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ژورنال
عنوان ژورنال: Hereditary Genetics
سال: 2012
ISSN: 2161-1041
DOI: 10.4172/2161-1041.1000114